Anti-Human POU4F2 Polyclonal Antibody|抗人POU4F2多克隆抗体(靶标：人POU结构域类转录因子4F2/BRN3B)
- 货号：RB9THC274024
- 价格：面议
- 点击：522
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Human, Mouse |
| 靶标 | BRN3B, Brain-3B, Brain-specific homeobox/POU domain protein 3B, Brn-3B, POU domain, class 4, transcription factor 2, POU4F2 |
| 免疫原 | E. coli - derived recombinant Human POU4F2 (Ser243-Ile409). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q12837 |
| 背景信息 | POU domain, class 4, transcription factor 2 (POU4F2) is a ~43 kDa protein. Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. 1. Salichs, E. et al. (2009) PLoS genetics 5, e1000397. PMID: 19266028 2. Zhang, L. et al. (2013) Molecular vision 19, 1371-86. PMID: 23805044 |
| 备注 | For research use only |
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