Anti-Human DKC1 Polyclonal Antibody|抗人DKC1多克隆抗体(靶标：人Dyskerin蛋白)
- 货号：RB9THD599014
- 价格：面议
- 点击：355
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Rat, Human |
| 靶标 | CBF5 homolog, DKC1, Dyskerin, EC:5.4.99.-, H/ACA ribonucleoprotein complex subunit DKC1, NOLA4, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoR |
| 免疫原 | E. coli - derived recombinant Human DKC1 (Glu82-Ser295). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O60832 |
| 背景信息 | H/ACA ribonucleoprotein complex subunit DKC1 is a ~57 kDa protein. Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. 1. Schwartz, S. et al. (2014) Cell 159, 148-162. PMID: 25219674 2. Balogh, E. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 15137-15147. PMID: 32554502 3. Venteicher, AS. et al. (2009) Science (New York, N.Y.) 323, 644-8. PMID: 19179534 |
| 备注 | For research use only |
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