Anti-Human CDH1/CDH11 Recombinant Antibody, APC|抗人CDH1/CDH11重组抗体, APC标记(靶标：人E-钙黏蛋白/钙黏蛋白11(APC标记))
- 货号：RB9THY460337
- 价格：面议
- 点击：695
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Mouse |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2a, kappa |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | FCM |
| 种属反应性 | Human |
| 靶标 | CAM 120/80, CD324, CDH1, CDHE, Cadherin-1, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, E-cadherin, Epithelial cadherin, UVO, Uvomorulin, CDH11, Cadherin-11, OB-cadherin, OSF-4, Osteoblast cadherin |
| 标记/偶联物 | APC |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
| 稳定性和储存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 登录号 | P12830, P55287 |
| 背景信息 | Cadherin-1 (CDH1/CDH11) is a ~97 kDa protein. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via its interaction with AMOTL2 which facilitates anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane. Plays a role in the early stages of desmosome cell-cell junction formation via facilitating the recruitment of DSG2 and DSP to desmosome plaques. 1. Meigs, TE. et al. (2002) The Journal of biological chemistry 277, 24594-600. PMID: 11976333 2. Shafraz, O. et al. (2018) eLife 7. PMID: 29999492 |
| 备注 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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