Anti-CYP26B1 Polyclonal Antibody|抗CYP26B1多克隆抗体(靶标：细胞色素P450家族26亚家族B成员1)
- 货号：RB9THV995014
- 价格：面议
- 点击：880
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | CYP26A2, CYP26B1, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, EC:1.14.13.-, P450RAI2, Retinoic acid-metabolizing cytochrome |
| 免疫原 | E. coli - derived recombinant human CYP26B1 (Thr97-Val512). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9NR63 |
| 观测分子量 | 53 kDa |
| 背景信息 | Cytochrome P450 26B1 is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination. Involved in the convertion of atRA to all-trans-4-oxo-RA. 1. White, JA. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 6403-8. PMID: 10823918 2. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119 3. Laue, K. et al. (2011) American journal of human genetics 89, 595-606. PMID: 22019272 |
| 备注 | For research use only |
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