| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | High affinity sodium-glucose cotransporter, NAGT, Na(+)/glucose cotransporter 1, SGLT1, SLC5A1, Sodium/glucose cotransporter 1, Solute carrier family 5 member 1 |
| 免疫原 | E. coli - derived recombinant Human SLC5A1 (Asp230-Pro277&Ser335-Gly380&Arg564-Thr643). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P13866 |
| 背景信息 | Sodium/glucose cotransporter 1 (SLC5A1) is a ~73 kDa protein. Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. 1. Hummel, CS. et al. (2011) American journal of physiology. Cell physiology 300, C14-21. PMID: 20980548 2. Han, L. et al. (2022) Nature 601, 274-279. PMID: 34880492 3. Kamitori, K. et al. (2022) Journal of molecular biology 434, 167464. PMID: 35077764 4. Martín, MG. et al. (1996) Nature genetics 12, 216-20. PMID: 8563765 5. Cui, W. et al. (2023) Nature communications 14, 2920. PMID: 37217492 6. Salker, MS. et al. (2017) Scientific reports 7, 12612. PMID: 28974690 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 羊抗鸡IgY抗体(精品) | 7447 |
| 鼠抗人IgG(单抗) | 6975 |
| 鼠抗人IgM(单抗) | 7249 |
| 新冠病毒N单抗IgG人源化质控品 | 7727 |
| 新冠病毒N单抗IgM人源化质控品 | 7353 |
| 三聚氰胺单抗 | 6976 |
| 纳他霉素单抗 | 7380 |
| 孔雀石绿单抗 | 7051 |
| 隐性孔雀石绿单抗 | 7160 |
| 微囊藻毒素LR单抗 | 7074 |
| 黄曲霉毒素B1单抗 | 6795 |
| 黄曲霉毒素M1单抗 | 6398 |
| T2毒素单抗 | 6825 |
| 赭曲霉毒素单抗 | 6642 |
| 呕吐毒素单抗 | 6735 |
| 伏马毒素单抗 | 7050 |
| 黄曲霉总量单抗B1 | 6230 |
| 黄曲霉总量单抗B2 | 6730 |
| 黄曲霉总量单抗G1 | 6498 |
| 黄曲霉总量单抗G2 | 6387 |