当前位置:首页>产品中心>单抗/多抗>Anti-Human USP48 Polyclonal Antibody|抗人USP48多克隆抗体(靶标:人泛素特异性蛋白酶48)

Anti-Human USP48 Polyclonal Antibody|抗人USP48多克隆抗体(靶标:人泛素特异性蛋白酶48)

  • 货号:RB9THB559024
  • 价格:面议
  • 点击:331
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human, Rat, Mouse
靶标Deubiquitinating enzyme 48, EC:3.4.19.12, USP31, USP48, Ubiquitin carboxyl-terminal hydrolase 48, Ubiquitin thioesterase 48, Ubiquitin-specific peptidase 48, Ubiquitin-specific protease 48, Ubiquitin-
免疫原E. coli - derived recombinant Human USP48 (Gln423-Val559).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号Q86UV5
背景信息

Ubiquitin carboxyl-terminal hydrolase 48 (USP48) is a ~119 kDa protein. Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability.

1. Tzimas, C. et al. (2006) Cellular signalling 18, 83-92. PMID: 16214042
2. Bassani, S. et al. (2021) Human molecular genetics 30, 1785-1796. PMID: 34059922
3. Antao, AM. et al. (2021) International journal of molecular sciences 22. PMID: 34445214
4. Jantaree, P. et al. (2022) Cellular and molecular life sciences : CMLS 79, 461. PMID: 35913642
5. Sánchez-Bellver, L. et al. (2022) International journal of molecular sciences 23. PMID: 36293380
6. Ren, Y. et al. (2023) Cancer research 83, 1074-1093. PMID: 36607699
备注For research use only
【仅供科学研究使用】

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