Anti-Human TSHR Polyclonal Antibody|抗人TSHR多克隆抗体(靶标：人促甲状腺激素受体)
- 货号：RB9THB852014
- 价格：面议
- 点击：425
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | LGR3, TSH-R, TSHR, Thyroid-stimulating hormone receptor, Thyrotropin receptor |
| 免疫原 | E. coli - derived recombinant Human TSHR (Ser26-Ser278). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P16473 |
| 背景信息 | Thyrotropin receptor (TSHR) is a ~86 kDa protein. Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS). 1. Costagliola, S. et al. (2002) The EMBO journal 21, 504-13. PMID: 11847099 2. Nakabayashi, K. et al. (2002) The Journal of clinical investigation 109, 1445-52. PMID: 12045258 3. Faust, B. et al. (2022) Nature 609, 846-853. PMID: 35940205 4. Duan, J. et al. (2022) Nature 609, 854-859. PMID: 35940204 5. Morgan, SJ. et al. (2016) Thyroid : official journal of the American Thyroid Association 26, 1794-1803. PMID: 27638195 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 倍硫磷单抗 | 6234 |
| 多菌灵/阿苯达唑二合一单抗 | 6279 |
| 三氯噻嗪单抗 | 6380 |
| 吡唑醚菌酯单抗 | 6593 |
| 烯酰吗啉单抗 | 6376 |
| 抑霉唑单抗 | 6133 |
| 恶醚唑（苯醚甲环唑）单抗 | 6310 |
| 赛拉嗪（甲苯噻嗪）单抗 | 6345 |
| 辛硫磷单抗 | 6393 |
| 多效唑单抗 | 6240 |
| 对硫磷单抗 | 6484 |
| 丙溴磷单抗 | 6474 |
| 戊唑醇单抗 | 6466 |
| 莠去津单抗 | 6395 |
| 灭蝇胺单抗 | 6083 |
| 尼卡巴嗪代谢物（DNC）单抗 | 6372 |
| 2.4-二氯苯氧乙酸单抗 | 6231 |
| 甲基对硫磷单抗 | 6312 |
| 左旋咪唑单抗 | 6236 |
| 三唑磷单抗 | 6297 |