Anti-Human TSHR Polyclonal Antibody|抗人TSHR多克隆抗体(靶标：人促甲状腺激素受体)
- 货号：RB9THB852014
- 价格：面议
- 点击：470
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | LGR3, TSH-R, TSHR, Thyroid-stimulating hormone receptor, Thyrotropin receptor |
| 免疫原 | E. coli - derived recombinant Human TSHR (Ser26-Ser278). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P16473 |
| 背景信息 | Thyrotropin receptor (TSHR) is a ~86 kDa protein. Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS). 1. Costagliola, S. et al. (2002) The EMBO journal 21, 504-13. PMID: 11847099 2. Nakabayashi, K. et al. (2002) The Journal of clinical investigation 109, 1445-52. PMID: 12045258 3. Faust, B. et al. (2022) Nature 609, 846-853. PMID: 35940205 4. Duan, J. et al. (2022) Nature 609, 854-859. PMID: 35940204 5. Morgan, SJ. et al. (2016) Thyroid : official journal of the American Thyroid Association 26, 1794-1803. PMID: 27638195 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 过氧化物酶（HRP）标莱克多巴胺单克隆抗体 | 5825 |
| 过氧化物酶（HRP）标沙丁胺醇单克隆抗体 | 5786 |
| 呋喃唑酮代谢物（2-NPAOZ）单抗 | 6269 |
| 环丙沙星（CPFX）单抗 | 5715 |
| 氟喹诺酮类单抗 | 5800 |
| 恩诺沙星单抗 | 5688 |
| 环丙沙星|恩诺沙星|诺氟沙星三合一单抗 | 5776 |
| 睾酮单抗 | 5695 |
| 过氧化物酶（HRP）标睾酮单克隆抗体 | 5586 |
| 过氧化物酶（HRP）标雌三醇单克隆抗体 | 5841 |
| 过氧化物酶（HRP）标记甲基睾酮单克隆抗体 | 6045 |
| 黄曲霉毒素抗体（黄曲霉毒素B1，黄曲霉毒素总量单克隆抗体） | 5648 |
| 苏丹红1号单抗 | 5968 |
| 呋喃西林代谢物（2-NPSEM）单抗（40F11细胞株） | 5552 |
| 小鼠单克隆抗体Ig类/亚类鉴定ELISA试剂盒 | 6454 |
| 小鼠单克隆抗体Ig类/亚类/亚型鉴定ELISA试剂盒 | 6729 |
| 小鼠单克隆抗体Ig类/亚类/亚型鉴定酶标二抗即用套装 | 6634 |
| HRP标记小鼠单抗专用稀释液 | 6672 |
| 小鼠单抗腹水制备专用佐剂套装 | 6720 |
| 新冠病毒S蛋白中和抗体ELISA检测试剂盒 | 6479 |