Anti-Human LRPPRC Polyclonal Antibody|抗人LRPPRC多克隆抗体(靶标：人富含亮氨酸的PPR基序含蛋白)
- 货号：RB9THC198014
- 价格：面议
- 点击：515
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | 130 kDa leucine-rich protein, GP130, LRP 130, LRP130, LRPPRC, Leucine-rich PPR motif-containing protein, mitochondrial |
| 免疫原 | E. coli - derived recombinant Human LRPPRC (Thr385-Asp725). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P42704 |
| 背景信息 | Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) is a ~157 kDa protein. May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex. Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm. May bind mature mRNA in the nucleus outer membrane. 1. Topisirovic, I. et al. (2009) The EMBO journal 28, 1087-98. PMID: 19262567 2. Volpon, L. et al. (2017) RNA (New York, N.Y.) 23, 927-937. PMID: 28325843 3. Zou, J. et al. (2013) The Biochemical journal 454, 447-57. PMID: 23822101 |
| 备注 | For research use only |
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