Anti-Human NASP Polyclonal Antibody|抗人NASP多克隆抗体(靶标：人核自身抗原精子蛋白)
- 货号：RB9THC209014
- 价格：面议
- 点击：771
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human, Rat |
| 靶标 | NASP, Nuclear autoantigenic sperm protein |
| 免疫原 | E. coli - derived recombinant Human NASP (Gly513-Gly681). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P49321 |
| 背景信息 | Nuclear autoantigenic sperm protein (NASP) is a ~85 kDa protein. Component of the histone chaperone network. Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy. Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. 1. Cook, AJ. et al. (2011) Molecular cell 44, 918-27. PMID: 22195965 |
| 备注 | For research use only |
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