| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat |
| 靶标 | 5-methyltetrahydrofolate--homocysteine methyltransferase, Cobalamin-dependent methionine synthase, EC:2.1.1.13, MS, MTR, Methionine synthase, Vitamin-B12 dependent methionine synthase |
| 免疫原 | E. coli - derived recombinant Human Methionine synthase/MTR (Leu924-Asp1265). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q99707 |
| 背景信息 | Methionine synthase (MTR) is a ~140 kDa protein. Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. 1. Yamada, K. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 9476-81. PMID: 16769880 2. Wolthers, KR. et al. (2007) The FEBS journal 274, 738-50. PMID: 17288554 3. Bassila, C. et al. (2017) Biochimica et biophysica acta. Molecular basis of disease 1863, 103-112. PMID: 27771510 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 阿苯达唑砜单抗 | 5548 |
| 金刚烷胺单抗 | 5605 |
| 卡那霉素单抗 | 5752 |
| 黄曲霉毒素M1(AFM1)单抗 | 5710 |
| 群勃龙(孕三烯酮)(去甲雄三烯醇酮)单抗 | 5929 |
| 帕托珠利(妥曲珠利砜)单抗 | 5615 |
| 泰乐菌素单抗 | 5667 |
| 替米考星单抗 | 5791 |
| 新霉素单抗 | 5760 |
| 安普霉素单抗 | 5714 |
| 三聚氰胺(MEL)单抗 | 5614 |
| 双氟沙星单抗 | 5572 |
| 西地那非单抗 | 5680 |
| 阿苯达唑单抗 | 5469 |
| 醋酸甲羟孕酮(醋酸甲孕酮)单抗 | 5657 |
| 氟苯尼考单抗 | 5684 |
| 诺龙单抗 | 5756 |
| 达氟沙星单抗 | 5885 |
| 培氟沙星单抗 | 5730 |
| 庆大霉素单抗 | 5878 |