Anti-Human HIPK2 Polyclonal Antibody|抗人HIPK2多克隆抗体(靶标：人同源域相互作用蛋白激酶2)
- 货号：RB9THC246014
- 价格：面议
- 点击：311
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Rat, Human |
| 靶标 | EC:2.7.11.1, HIPK2, Homeodomain-interacting protein kinase 2, hHIPk2 |
| 免疫原 | E. coli - derived recombinant Human HIPK2 (Gln188-Arg553). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9H2X6 |
| 背景信息 | Homeodomain-interacting protein kinase 2 (HIPK2) is a ~130 kDa protein. Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. 1. Liebl, MC. et al. (2021) Nucleic acids research 49, 2759-2776. PMID: 33591310 |
| 备注 | For research use only |
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