Anti-Human IL18/IL1F4 Polyclonal Antibody|抗人IL18/IL1F4多克隆抗体(靶标：人白细胞介素18/IL-1F4)
- 货号：RB9THC517024
- 价格：面议
- 点击：298
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | IFN-gamma-inducing factor, IGIF, IL-1 gamma, IL-18, IL18, IL1F4, Iboctadekin, Interferon gamma-inducing factor, Interleukin-1 gamma, Interleukin-18 |
| 免疫原 | E. coli - derived recombinant Human IL18/IL1F4 (Tyr37-Asp193). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q14116 |
| 背景信息 | Interleukin-18 (IL18/IL1F4) is a ~22 kDa protein. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293 3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532 4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 5. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| CA-125单克隆抗体 | 6785 |
| PSA单克隆抗体 | 6838 |
| AFP单克隆抗体 | 6799 |
| CA-724单克隆抗体 | 6796 |
| CA-199单克隆抗体 | 6694 |
| HE4单克隆抗体 | 6511 |
| 孕酮单克隆抗体 | 7067 |
| 人胎球蛋白A(Fetuin A)单克隆抗体 | 6996 |
| 胎盘泌乳素单克隆抗体 | 6801 |
| 泌乳素单克隆抗体 | 6575 |
| SP-10单克隆抗体 | 6705 |
| AMH单克隆抗体 | 7086 |
| 胎儿纤维链接蛋白单克隆抗体 | 6838 |
| HCG单克隆抗体 | 6727 |
| 人骨碱性磷酸酶单克隆抗体 | 6633 |
| 小分子单克隆抗体 | 6788 |
| 抗环瓜氨酸肽抗体(Anti-CCP)诊断试剂原料 | 6729 |
| 耐碳青霉烯单克隆抗体 | 6909 |
| 补体C4c单克隆抗体 | 7159 |
| 补体C3c单克隆抗体 | 6737 |