Anti-Human IL18/IL1F4 Polyclonal Antibody|抗人IL18/IL1F4多克隆抗体(靶标：人白细胞介素18/IL-1F4)
- 货号：RB9THC517024
- 价格：面议
- 点击：807
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | IFN-gamma-inducing factor, IGIF, IL-1 gamma, IL-18, IL18, IL1F4, Iboctadekin, Interferon gamma-inducing factor, Interleukin-1 gamma, Interleukin-18 |
| 免疫原 | E. coli - derived recombinant Human IL18/IL1F4 (Tyr37-Asp193). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q14116 |
| 背景信息 | Interleukin-18 (IL18/IL1F4) is a ~22 kDa protein. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293 3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532 4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 5. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744 |
| 备注 | For research use only |
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