Anti-Human SETD1A Polyclonal Antibody|抗人SETD1A多克隆抗体(靶标：人SET结构域含蛋白1A)
- 货号：RB9THC879014
- 价格：面议
- 点击：483
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | EC:2.1.1.364, Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, SET1, SET1A, SETD1A, Set1/Ash2 histone methyltransferase comp |
| 免疫原 | E. coli - derived recombinant Human SETD1A (Val1524-Ser1670). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O15047 |
| 背景信息 | Histone-lysine N-methyltransferase SETD1A is a ~186 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. 1. Wysocka, J. et al. (2003) Genes & development 17, 896-911. PMID: 12670868 2. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738 3. Higgs, MR. et al. (2018) Molecular cell 71, 25-41.e6. PMID: 29937342 4. Yu, X. et al. (2019) Neuroscience bulletin 35, 1045-1057. PMID: 31197650 5. Kummeling, J. et al. (2021) Molecular psychiatry 26, 2013-2024. PMID: 32346159 6. Amin, HM. et al. (2023) International journal of molecular sciences 24. PMID: 38003223 |
| 备注 | For research use only |
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