当前位置:首页>产品中心>单抗/多抗>Anti-Human HADHB Polyclonal Antibody|抗人HADHB多克隆抗体(靶标:人羟酰辅酶A脱氢酶β亚基)

Anti-Human HADHB Polyclonal Antibody|抗人HADHB多克隆抗体(靶标:人羟酰辅酶A脱氢酶β亚基)

  • 货号:RB9THD094014
  • 价格:面议
  • 点击:471

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human
靶标3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, EC:2.3.1.155, EC:2.3.1.16, HADHB, TP-beta, Trifunctional enzyme subunit beta, mitochondrial
免疫原E. coli - derived recombinant Human HADHB (Asn50-Ser284).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P55084
背景信息

Trifunctional enzyme subunit beta, mitochondrial (HADHB) is a ~51 kDa protein. Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.

1. Liang, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 7039-7044. PMID: 29915090
2. Xia, C. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 6069-6074. PMID: 30850536
3. Kamijo, T. et al. (1994) Biochemical and biophysical research communications 199, 818-25. PMID: 8135828
备注For research use only
【仅供科学研究使用】

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