| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | 5'-3' exoribonuclease DXO, DOM3L, DOM3Z, DXO, DeNADding enzyme DXO, Decapping and exoribonuclease protein, Dom-3 homolog Z, EC:3.1.13.-, EC:3.6.1.-, NAD-capped RNA hydrolase DXO, NG6 |
| 免疫原 | E. coli - derived recombinant Human DXO (Thr31-Lys396). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O77932 |
| 背景信息 | Decapping and exoribonuclease protein (DXO) is a ~44 kDa protein. Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to environmental stress. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. 1. Jiao, X. et al. (2017) Cell 168, 1015-1027.e10. PMID: 28283058 2. Grudzien-Nogalska, E. et al. (2019) Nature chemical biology 15, 575-582. PMID: 31101919 3. Picard-Jean, F. et al. (2018) PloS one 13, e0193804. PMID: 29601584 4. Doamekpor, SK. et al. (2020) Nucleic acids research 48, 6136-6148. PMID: 32374864 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| Trx鼠单抗标签 | 7181 |
| BrdU单抗 | 7300 |
| HRP-BrdU单抗 | 7084 |
| GAPDH 鼠单抗 | 6956 |
| HRP-GAPDH 鼠单抗 | 7044 |
| PCNA单抗 | 7340 |
| α-tubulin 鼠单抗 | 6992 |
| β-tubulin 鼠单抗 | 7342 |
| HRP-β-tubulin 鼠单抗 | 7157 |
| β-Actin 鼠单抗 | 7357 |
| HRP-β-Actin 鼠单抗 | 7043 |
| Histone H3鼠单抗 | 7093 |
| 糖基化血红蛋白单抗 | 7317 |
| 糖基化血红蛋白抗体 | 7340 |
| C肽鼠单抗 | 6659 |
| 胰岛素鼠单抗 | 7027 |
| 胃蛋白酶原II鼠单抗 | 7102 |
| 鼠抗人胃泌素17单抗 | 7006 |
| 心肌钙蛋白鼠单抗(CTNI抗体) | 7087 |
| 肌红蛋白鼠单抗 | 7197 |