当前位置:首页>产品中心>单抗/多抗>Anti-Human RAB32 Polyclonal Antibody|抗人RAB32多克隆抗体(靶标:人Ras相关蛋白Rab32)

Anti-Human RAB32 Polyclonal Antibody|抗人RAB32多克隆抗体(靶标:人Ras相关蛋白Rab32)

  • 货号:RB9THD207014
  • 价格:面议
  • 点击:256

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human
靶标EC:3.6.5.2, RAB32, Ras-related protein Rab-32
免疫原E. coli - derived recombinant Human RAB32 (Met1-Cys225).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号Q13637
背景信息

Ras-related protein Rab-32 (RAB32) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

1. Bao, X. et al. (2002) European journal of biochemistry 269, 259-71. PMID: 11784320
2. Nottingham, RM. et al. (2011) The Journal of biological chemistry 286, 33213-22. PMID: 21808068
3. Alto, NM. et al. (2002) The Journal of cell biology 158, 659-68. PMID: 12186851
4. Seto, S. et al. (2011) Traffic (Copenhagen, Denmark) 12, 407-20. PMID: 21255211
5. Gerondopoulos, A. et al. (2012) Current biology : CB 22, 2135-9. PMID: 23084991
6. Zhu, H. et al. (2023) Science (New York, N.Y.) 382, 1404-1411. PMID: 38127736
备注For research use only
【仅供科学研究使用】

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