Anti-Mouse TRADD Polyclonal Antibody|抗小鼠TRADD多克隆抗体(靶标：小鼠TNFRSF1A相关死亡结构域蛋白)
- 货号：RB9TMS785014
- 价格：面议
- 点击：245
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse |
| 靶标 | TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD, Tumor necrosis factor receptor type 1-associated DEATH domain protein |
| 免疫原 | E. coli - derived recombinant Mouse TRADD (Trp11-Gln142). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q3U0V2 |
| 背景信息 | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a ~34 kDa protein. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. 1. Chio, II. et al. (2012) Nature cell biology 14, 625-33. PMID: 22561347 |
| 备注 | For research use only |
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