Anti-Human DLG5 Polyclonal Antibody|抗人DLG5多克隆抗体(靶标：人盘状大同源物5)
- 货号：RB9THV023014
- 价格：面议
- 点击：1139
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | DLG5, Discs large protein P-dlg, Disks large homolog 5, KIAA0583, PDLG, Placenta and prostate DLG |
| 免疫原 | E. coli - derived recombinant Human DLG5 (Val1742-Asn1909). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q8TDM6 |
| 背景信息 | Disks large homolog 5 (DLG5) is a ~213 kDa protein. Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. 1. Kwan, J. et al. (2016) Genes & development 30, 2696-2709. PMID: 28087714 2. Liu, J. et al. (2017) Scientific reports 7, 42125. PMID: 28169360 |
| 备注 | For research use only |
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