Anti-Rat DIO1 Polyclonal Antibody|抗大鼠DIO1多克隆抗体(靶标：大鼠碘甲状腺原氨酸脱碘酶1)
- 货号：RB9TRW476014
- 价格：面议
- 点击：282
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Mouse |
| 靶标 | 5DI, DIO1, DIOI, EC:1.21.99.3, EC:1.21.99.4, ITDI1, TXDI1, Type 1 DI, Type I iodothyronine deiodinase, Type-I 5'-deiodinase |
| 免疫原 | E. coli - derived recombinant Rat DIO1 (Arg85-Phe257). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P24389 |
| 背景信息 | Type I iodothyronine deiodinase (DIO1) is a ~29 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine(3-T1) and 3,3'-diiodothyronine (3,3'-T2) to 3-T1 via inner-ring deiodination (IRD). Catalyzes the deiodination of rT3 to 3,3'-T2 via ORD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine, 3',5'-diiodothyronamine and 3,3'-diiodothyronamine as well as tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine. 1. Berry, MJ. (1992) The Journal of biological chemistry 267, 18055-9. PMID: 1517238 2. Leonard, JL. et al. (1991) The Journal of biological chemistry 266, 11262-9. PMID: 2040632 3. Toyoda, N. et al. (1995) The Journal of biological chemistry 270, 12310-8. PMID: 7744884 4. Berry, MJ. et al. (1991) Nature 349, 438-40. PMID: 1825132 5. Moreno, M. et al. (1994) FEBS letters 344, 143-6. PMID: 8187873 |
| 备注 | For research use only |
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