Anti-Human NR3C1 Polyclonal Antibody|抗人NR3C1多克隆抗体(靶标：人核受体亚家族3C组1/糖皮质激素受体)
- 货号：RB9THY450014
- 价格：面议
- 点击：290
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human, Rat |
| 靶标 | GR, GRL, Glucocorticoid receptor, NR3C1, Nuclear receptor subfamily 3 group C member 1 |
| 免疫原 | E. coli - derived recombinant Human NR3C1 (Ser555-Lys777). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P04150 |
| 背景信息 | Glucocorticoid receptor (NR3C1) is a ~85 kDa protein. Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. 1. Vitellius, G. et al. (2016) Human mutation 37, 794-803. PMID: 27120390 2. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 3. Fadda, A. et al. (2017) Scientific reports 7, 41598. PMID: 28139699 4. Fryer, CJ. et al. (1998) Nature 393, 88-91. PMID: 9590696 5. Cho, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E1540-9. PMID: 25775514 |
| 备注 | For research use only |
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