Anti-Mouse PPIA Polyclonal Antibody|抗小鼠PPIA多克隆抗体(靶标：小鼠肽基脯氨酰顺反异构酶A/亲环蛋白A)
- 货号：RB9TMX128014
- 价格：面议
- 点击：591
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Mouse, Human |
| 靶标 | Cyclophilin A, Cyclosporin A-binding protein, EC:5.2.1.8, PPIase A, Peptidyl-prolyl cis-trans isomerase A, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed, Ppia, Rotamase A, SP18 |
| 免疫原 | E. coli - derived recombinant Mouse PPIA (Met1-Leu164). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P17742 |
| 背景信息 | Peptidyl-prolyl cis-trans isomerase A (PPIA) is a ~17 kDa protein. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. 1. Wang, L. et al. (2014) Thrombosis and haemostasis 111, 873-82. PMID: 24429998 2. Lauranzano, E. et al. (2015) Brain : a journal of neurology 138, 974-91. PMID: 25678563 |
| 备注 | For research use only |
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