Anti-Human HCAR2 Polyclonal Antibody|抗人HCAR2多克隆抗体(靶标：人羟基羧酸受体2)
- 货号：RB9THD417014
- 价格：面议
- 点击：729
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | G-protein coupled receptor 109A, G-protein coupled receptor HM74A, GPR109A, HCA2, HCAR2, HM74A, Hydroxycarboxylic acid receptor 2, NIACR1, Niacin receptor 1, Nicotinic acid receptor |
| 免疫原 | E. coli - derived recombinant Human HCAR2 (Asn2-Val33&Tyr295-Pro363). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q8TDS4 |
| 背景信息 | Hydroxycarboxylic acid receptor 2 (HCAR2) is a ~41 kDa protein. Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. |
| 备注 | For research use only |
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