Anti-Human CBX5 Polyclonal Antibody|抗人CBX5多克隆抗体(靶标：人染色盒同源物5/HP1α)
- 货号：RB9T37037022
- 价格：面议
- 点击：895
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | Antigen p25, CBX5, Chromobox protein homolog 5, HP1 alpha, HP1A, Heterochromatin protein 1 homolog alpha |
| 免疫原 | E. coli - derived recombinant Human CBX5 (Tyr20-Ser191). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P45973 |
| 背景信息 | Chromobox protein homolog 5 (CBX5) is a ~22 kDa protein. Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR). 1. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427 2. Dawson, MA. et al. (2009) Nature 461, 819-22. PMID: 19783980 3. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177 4. Kiyomitsu, T. et al. (2010) The Journal of cell biology 188, 791-807. PMID: 20231385 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 过氧化物酶（HRP）标莱克多巴胺单克隆抗体 | 6751 |
| 过氧化物酶（HRP）标沙丁胺醇单克隆抗体 | 6934 |
| 呋喃唑酮代谢物（2-NPAOZ）单抗 | 7378 |
| 环丙沙星（CPFX）单抗 | 6839 |
| 氟喹诺酮类单抗 | 6855 |
| 恩诺沙星单抗 | 6829 |
| 环丙沙星|恩诺沙星|诺氟沙星三合一单抗 | 6758 |
| 睾酮单抗 | 6627 |
| 过氧化物酶（HRP）标睾酮单克隆抗体 | 6721 |
| 过氧化物酶（HRP）标雌三醇单克隆抗体 | 7122 |
| 过氧化物酶（HRP）标记甲基睾酮单克隆抗体 | 7214 |
| 黄曲霉毒素抗体（黄曲霉毒素B1，黄曲霉毒素总量单克隆抗体） | 6710 |
| 苏丹红1号单抗 | 6897 |
| 呋喃西林代谢物（2-NPSEM）单抗（40F11细胞株） | 6657 |
| 小鼠单克隆抗体Ig类/亚类鉴定ELISA试剂盒 | 7503 |
| 小鼠单克隆抗体Ig类/亚类/亚型鉴定ELISA试剂盒 | 7722 |
| 小鼠单克隆抗体Ig类/亚类/亚型鉴定酶标二抗即用套装 | 7653 |
| HRP标记小鼠单抗专用稀释液 | 7807 |
| 小鼠单抗腹水制备专用佐剂套装 | 7823 |
| 新冠病毒S蛋白中和抗体ELISA检测试剂盒 | 7410 |
