Anti-Human FIG4 Polyclonal Antibody|抗人FIG4多克隆抗体(靶标：人FIG4磷酸肌醇-5-磷酸酶)
- 货号：RB9THP232014
- 价格：面议
- 点击：535
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | EC:3.1.3.-, EC:3.1.3.16, EC:3.1.3.36, EC:3.1.3.86, FIG4, KIAA0274, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, Polyphosphoinositide phosphatase, SAC domain-containing protein 3, SAC3, Serine- |
| 免疫原 | E. coli - derived recombinant Human FIG4 (Gly216-His665). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q92562 |
| 背景信息 | Polyphosphoinositide phosphatase (FIG4) is a ~103 kDa protein. Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. 1. Sbrissa, D. et al. (2007) The Journal of biological chemistry 282, 23878-91. PMID: 17556371 2. Lees, JA. et al. (2020) Molecular cell 80, 736-743.e4. PMID: 33098764 |
| 备注 | For research use only |
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