Anti-Human SH3RF1 Polyclonal Antibody|抗人SH3RF1多克隆抗体(靶标：人SH3结构域含环指蛋白1)
- 货号：RB9T37036981
- 价格：面议
- 点击：1008
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | E3 ubiquitin-protein ligase SH3RF1, EC:2.3.2.27, KIAA1494, POSH, POSH1, Plenty of SH3s, Protein POSH, RING finger protein 142, RING-type E3 ubiquitin transferase SH3RF1, RNF142, SH3 domain-containing |
| 免疫原 | E. coli - derived recombinant Human SH3RF1 (Gln135-Lys268). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q7Z6J0 |
| 背景信息 | E3 ubiquitin-protein ligase SH3RF1 is a ~93 kDa protein. Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. 1. Alroy, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1478-83. PMID: 15659549 2. Kärkkäinen, S. et al. (2010) FEBS letters 584, 3867-72. PMID: 20696164 3. Lin, DH. et al. (2009) The Journal of biological chemistry 284, 29614-24. PMID: 19710010 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 炔诺酮单抗 | 6938 |
| 磺胺氯吡嗪单抗 | 6863 |
| 呋喃苯烯酸钠单抗 | 6386 |
| 呋喃它酮代谢物（2-NPAMOZ）单抗 | 6438 |
| 呋喃西林代谢物（2-NPSEM）单抗 | 6200 |
| 磺胺喹恶啉单抗 | 6735 |
| 苯丙酸诺龙单抗 | 6665 |
| 司帕沙星单抗 | 6243 |
| 妥布霉素单抗 | 6502 |
| 甲氧氯普胺单抗 | 6186 |
| 莫能菌素单抗 | 6464 |
| 多粘菌素B（粘菌素）单抗 | 6967 |
| 磺胺类单抗 | 7105 |
| 托灭酸（托芬那酸）单抗 | 6153 |
| 卡洛芬单抗 | 6229 |
| 喹乙醇代谢物MQCA单抗 | 6271 |
| 氟尼辛单抗 | 6677 |
| 磺胺二甲嘧啶（SM2）单抗 | 6156 |
| 诺龙（19-去甲睾酮）单抗 | 6178 |
| 阿苯达唑-2-氨基砜单抗 | 6100 |
