Anti-Human HNRNPD Polyclonal Antibody|抗人HNRNPD多克隆抗体(靶标：人异质核核糖核蛋白D)
- 货号：RB9THD584014
- 价格：面议
- 点击：893
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | AU-rich element RNA-binding protein 1, AUF1, HNRNPD, HNRPD, Heterogeneous nuclear ribonucleoprotein D0, hnRNP D0 |
| 免疫原 | E. coli - derived recombinant Human HNRNPD (His86-Lys255). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q14103 |
| 背景信息 | Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) is a ~38 kDa protein. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. |
| 备注 | For research use only |
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