Anti-Human CIP2A Polyclonal Antibody|抗人CIP2A多克隆抗体(靶标：人蛋白磷酸酶2A抑制剂/CIP2A)
- 货号：RB9THV712014
- 价格：面议
- 点击：565
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | CIP2A, Cancerous inhibitor of PP2A, KIAA1524, Protein CIP2A, p90 autoantigen |
| 免疫原 | E. coli - derived recombinant Human CIP2A (Asp2-Glu560). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q8TCG1 |
| 背景信息 | Protein CIP2A is a ~102 kDa protein. Acts as an inhibitor of protein phosphatase PP2A. Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies. Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei. Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss. 1. Junttila, MR. et al. (2007) Cell 130, 51-62. PMID: 17632056 2. Adam, S. et al. (2021) Nature cancer 2, 1357-1371. PMID: 35121901 3. De Marco Zompit, M. et al. (2022) Nature communications 13, 4143. PMID: 35842428 4. Lin, YF. et al. (2023) Nature 618, 1041-1048. PMID: 37165191 5. Trivedi, P. et al. (2023) Nature 618, 1049-1056. PMID: 37316668 |
| 备注 | For research use only |
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