Anti-Human PLA2G10 Polyclonal Antibody|抗人PLA2G10多克隆抗体(靶标：人磷脂酶A2-X)
- 货号：RB9THT102014
- 价格：面议
- 点击：494
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | EC:3.1.1.4, GX sPLA2, Group 10 secretory phospholipase A2, Group X secretory phospholipase A2, PLA2G10, Phosphatidylcholine 2-acylhydrolase 10, sPLA2-X |
| 免疫原 | E. coli - derived recombinant Human PLA2G10 (Glu32-Asp165). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O15496 |
| 背景信息 | Group 10 secretory phospholipase A2 (PLA2G10) is a ~18 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells. 1. Hanasaki, K. et al. (2002) The Journal of biological chemistry 277, 29116-24. PMID: 12021277 2. Cupillard, L. et al. (1997) The Journal of biological chemistry 272, 15745-52. PMID: 9188469 3. Singer, AG. et al. (2002) The Journal of biological chemistry 277, 48535-49. PMID: 12359733 4. Gora, S. et al. (2006) Biochimica et biophysica acta 1761, 1093-9. PMID: 16962371 5. Koduri, RS. et al. (2002) The Journal of biological chemistry 277, 5849-57. PMID: 11694541 6. Mitsuishi, M. et al. (2006) The Biochemical journal 393, 97-106. PMID: 16146426 |
| 备注 | For research use only |
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