| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | Adipsin, C3 convertase activator, CFD, Complement factor D, DF, EC:3.4.21.46, PFD, Properdin factor D |
| 免疫原 | E. coli - derived recombinant Human CFD (Met1-Ala253). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P00746 |
| 背景信息 | Complement factor D (CFD) is a ~27 kDa protein. Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway. 1. Forneris, F. et al. (2010) Science (New York, N.Y.) 330, 1816-20. PMID: 21205667 2. Katschke, KJ. et al. (2012) The Journal of biological chemistry 287, 12886-92. PMID: 22362762 3. Niemann, MA. et al. (1980) Biochemistry 19, 1576-83. PMID: 6769474 4. Volanakis, JE. et al. (1977) Journal of immunology (Baltimore, Md. : 1950) 119, 337-42. PMID: 874324 5. Hourcade, DE. et al. (1998) The Journal of biological chemistry 273, 25996-6000. PMID: 9748277 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 氯丙嗪单抗 | 6672 |
| 西马特罗单抗 | 6832 |
| 孕酮单抗 | 6829 |
| 氯霉素(CAP)单抗 | 6909 |
| 红霉素单抗 | 6866 |
| 地克珠利单抗 | 6327 |
| 无色孔雀石绿(LMG)单抗 | 6582 |
| 雌二醇单抗 | 6608 |
| 孔雀石绿(MG)单抗 | 6784 |
| 双酚A单抗 | 6693 |
| 呋喃妥因代谢物(2-NPAHD)单抗 | 6533 |
| 己烯雌酚单抗 | 6663 |
| 莱克多巴胺(RAC)单抗 | 6773 |
| 林可霉素单抗 | 7858 |
| 抗青霉素受体单抗 | 6393 |
| 大观霉素单抗 | 6582 |
| 克伦特罗(CL)单抗 | 6784 |
| 沙拉沙星单抗(2H4) | 6732 |
| 磺胺对甲氧嘧啶(SMD)单抗 | 6601 |
| 磺胺类SAS单抗 | 6642 |