当前位置：首页>产品中心>单抗/多抗>InVivo Plus Mouse CTLA-4 Antibody(9D9)|InVivo Plus小鼠CTLA-4抗体(靶标：小鼠细胞毒性T淋巴细胞相关蛋白4/CD152)
InVivo Plus Mouse CTLA-4 Antibody(9D9)|InVivo Plus小鼠CTLA-4抗体(靶标：小鼠细胞毒性T淋巴细胞相关蛋白4/CD152)
- 货号：RB9T37033583
- 价格：面议
- 点击：697
产品介绍
产品参数
| 产品描述 | The 9D9 monoclonal antibody recognizes mouse CTLA-4 (CD152), a 33-kDa CD28-family inhibitory receptor expressed on activated T and B cells. CTLA-4 binds the B7 ligands CD80 and CD86 and delivers negative regulatory signals that control T-cell activation, maintain tolerance, and support normal immune homeostasis. The essential role of CTLA-4 is highlighted by CTLA-4–deficient mice, which develop fatal lymphoproliferation. As a key immune checkpoint, CTLA-4 is a major target in cancer immunotherapy. The 9D9 antibody is widely used for CTLA-4 blockade and has been shown in multiple tumor models to mediate effective in vivo depletion of intratumoral regulatory T cells. |
|---|---|
| 形态 | Liquid |
| 宿主种属 | Mouse |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2b, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | <1 EU/mg |
| 应用 | in vivo CTLA-4 neutralization, WB, in vivo intra-tumoral regulatory T cell depletion |
| 种属反应性 | Mouse |
| 靶标 | CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 登录号 | P09793 |
| 备注 | For research use only. |
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