当前位置：首页>产品中心>单抗/多抗>InVivo Plus Mouse CD40/TNFRSF5 Antibody(FGK45)|InVivo Plus小鼠CD40/TNFRSF5抗体(靶标：小鼠肿瘤坏死因子受体超家族成员5/CD40)
InVivo Plus Mouse CD40/TNFRSF5 Antibody(FGK45)|InVivo Plus小鼠CD40/TNFRSF5抗体(靶标：小鼠肿瘤坏死因子受体超家族成员5/CD40)
- 货号：RB9T37033580
- 价格：面议
- 点击：562
产品介绍
产品参数
| 产品描述 | The FGK4.5 monoclonal antibody recognizes mouse CD40 (Bp50), a 48-kDa type I transmembrane glycoprotein of the TNFR superfamily. CD40 is broadly expressed on antigen-presenting cells-including dendritic cells, B cells, macrophages, and monocytes-as well as various non-immune cells and tumors. Through engagement with its ligand CD154, CD40 provides key costimulatory signals that drive B-cell activation, differentiation, proliferation, class switching, and dendritic cell maturation. Agonistic CD40 antibodies can activate APCs and enhance anti-tumor T-cell responses. FGK4.5 is an agonistic anti-CD40 antibody that activates CD40+ APCs and can also block CD40–CD154 interactions in vitro and in vivo. |
|---|---|
| 形态 | Liquid |
| 宿主种属 | Rat |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2a, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | <1 EU/mg |
| 应用 | in vivo NK cell depletion, FCMin vivo CD40 activation, in vitro B cell stimulation/activation |
| 种属反应性 | Mouse |
| 靶标 | Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, TNFRSF5, CDw40, CD40 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 登录号 | P27512 |
| 备注 | For research use only. |
相关产品:
