Recombinant Mouse IL-4 (C-6His)

产品介绍

{"gui_ge":"10ug","biao_da_su_zhu":"Human Cells","biao_qian":"C-6His","fen_zi_liang":"14.6 KDa","biao_guan_fen_zi_liang":"15-19 KDa, reducing conditions","xing_tai":"Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.","chun_du":"Greater than 95% as determined by reducing SDS-PAGE.","nei_du_su_shui_ping":"Less than 0.1 ng\/µg (1 EU\/µg) as determined by LAL test.","huo_xing":"Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells.  The ED50 for this effect is 0.035 ng\/ml.","rong_jie_fang_fa":"Always centrifuge tubes before opening.Do not mix by vortex or pipetting.\nIt is not recommended to reconstitute to a concentration less than 100μg\/ml.\nDissolve the lyophilized protein in distilled water.\nPlease aliquot the reconstituted solution to minimize freeze-thaw cycles. ","chu_cun_fang_fa":"Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.\nReconstituted protein solution can be stored at 4-7°C for 2-7 days.\nAliquots of reconstituted samples are stable at < -20°C for 3 months.","yun_shu_tiao_jian":"The product is shipped at ambient temperature.\nUpon receipt, store it immediately at the temperature listed below.","bei_jing_shuo_ming":"Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response."}