Recombinant Mouse Thrombomodulin (C-6His)
- 货号：EPT230
- 价格：￥1,800.00 元
- 点击：1181
产品介绍
基本信息
| 规格 | 10ug |
|---|
| 表达宿主 | Human Cells |
|---|
| 标签 | C-6His |
|---|
物理性质
| 分子量 | 54.6 KDa |
|---|
| 表观分子量 | 85-90 KDa, reducing conditions |
|---|
| 形态 | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
|---|
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
|---|
活性与内毒素
| 内毒素水平 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
|---|
储存与运输
| 储存方法 | Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles. |
|---|
| 运输条件 | The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below. |
|---|
详细说明
| 背景说明 | Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. |
|---|
