Recombinant 2019-nCoV S1 Protein (C-6His)
- 货号：EPT049
- 价格：￥2,550.00 元
- 点击：1172
产品介绍
基本信息
| 规格 | 50ug |
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| 表达宿主 | Human Cells |
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| 标签 | C-6His |
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物理性质
| 分子量 | 75.8kDa |
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| 表观分子量 | 100-130kDa, reducing conditions |
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| 形态 | Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 |
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| 纯度 | Greater than 90% as determined by reducing SDS-PAGE. |
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活性与内毒素
| 活性 | Immobilized 2019-nCoV S1-His (Cat#DRA47) at 5μg/ml (100 μl/well) can bind Human ACE-2-Fc(Cat#C05Y).The ED50 of Recombinant Human ACE-2-Fc(Cat#C05Y) is 58.3 ng/ml. |
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储存与运输
| 储存方法 | Reconstituted protein solution should be stored at ≤ -20°C. |
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| 运输条件 | The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below. |
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详细说明
| 背景说明 | The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. |
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